Biontech, Moderna, Astrazeneca: Who causes most common side effects?

Biontech, Moderna, Astrazeneca: Who causes most common side effects?
Female doctor wearing protective suit injecting vaccine into senior patient's arm

Biontech, Moderna, AstrazenecaWhich vaccine causes most common side effects? Many people are concerned with the question of which side effects can occur in corona vaccination. An overview of all reported reactions – from fever to anaphylaxis.

In Germany, the Paul-Ehrlich-Institut (PEI) monitors the safety of vaccines and medicines. To this end, the Department of Medicinal Safety collects and evaluates reports on undesirable effects. Security reports are published regularly, which also contain all suspects of side effects or vaccine complications reported in Germany related to Covid-19 vaccines.

By 4 March, according to the Robert Koch Institute, around 5.91 million people were vaccinated against Covid-19. The most commonly administered vaccine is BNT162b2 from biontech/Pfizer with 5.378.703 vaccinations. Behind this follow 363.645 vaccinations with the vector vaccine of Astrazeneca and 168.189 vaccinations with the Moderna vaccine.

Most of the side effects – 83.2 percent – were not classified as serious. The ten most common side effects of corona vaccinationVarious vaccination reactions and side effects have been reported in the currently inoculated corona active substances from Biontech/Pfizer, Moderna and Astrazeneca. According to the PEI, these are primarily “pre-transverse local reactions and general reactions” which have already occurred in clinical investigations.

According to the PEI, one of the ten most common vaccine reactions in all vaccines authorised in Germany is:Fever headaches Shaking frost fatigue flu-like symptoms muscle pain at puncture dizziness weakness nauseaHere it goes: The side effects differ depending on the vaccine. Fieber is given as the most common side effect in all three means. In addition:at Biontechin the Moderna vaccine pain at the puncture site andin the Astrazeneca vaccine flu-like symptoms.

The Paul-Ehrlich-Institut receives the percentage of most reports on suspected cases of side effects after a corona vaccination. This is shown in the following table, which refers to data from the Security Report of 4th. March relies on:Cases per 1,000 vaccinations Average Biontech/Pfizer Moderna Astrazeneca total 2.0 1.6 2.9 7.6 severe 0.6 0.3 0.6 3.7In vaccinations with the vector vaccine of Astrazeneca, fever, chills and flu-like complaints have been found more frequently.

However, in the opinion of the PEI, this does not automatically mean that the vaccine is less compatible than the two mRNA vaccines. From the comparatively higher reporting rate of the Astrazeneca vaccine for non-heavy reactions, it cannot necessarily be concluded that, in connection with these vaccinations, frequently undesirable side effects of the vaccine occur, the PEI explains. The Covid-19 vaccine from Astrazeneca was awarded on 29th In January, the EU approval without age limit was allowed to be vaccinated only in 18 to 64 years old.

A further statement by the PEI: “Also many messages have been reported as being severely, although it has been, for example, temporary fever reactions,” says the current security report. “At least in the UK, there was no great difference in the reporting rates between Biontech/Pfizer and Astrazeneca,” PEI continued. According to case reports, vaccination against Covid-19 can also lead to swollen lymph nodes among the poor.

Lymph node swellings are, just like pain at the puncture site, generally common side effects of vaccinations and therefore not unusual. These reactions show that the body processes information about the pathogen to which the vaccination is to act. Even if the most common side effects are harmless and temporary, there are also severe undesirable reactions after the Covid-19 vaccination in rare cases.

In vaccination with the mRNA vaccines of Biontech and Moderna, for example, severe allergic reactions were reported. The vector virus vaccines from Astrazeneca and Johnson & Johnson do not contain PEG and could therefore be better tolerated for strong allergy sufferers. It is therefore recommended to monitor vaccines at least 15 minutes after vaccination in order to react appropriately to any allergic reactions.

Younger women more often affected by anaphylaxisIn connection with the mRNA vaccines, the term anaphylaxis is also repeatedly used. Certain antibodies are responsible for this, which the immune system has formed “respectfully” against substances that are actually harmless. In Germany, 67 cases of anaphylaxis after corona vaccination have been observed by the end of February.

According to RKI, established vaccines also have side effects. An overview of the side effects of long-dose vaccines:Seasonal flu vaccination is considered very safe. However, as any vaccination, it can cause redness or swelling at the puncture site (at 10 to 40 percent).

General symptoms such as fever, frogs or sweating, fatigue, head and muscle pain occur occasionally (at five to ten percent). Severe allergic reactions such as anaphylaxis are very rare (with less than one of 10,000 vaccinated persons). This must be controlled, as very high fever can result in a fever cramp (in one of 3,000 children).

It has a very high efficiency of 95 percent and is considered to be well tolerated. Fieber (in one to two children of ten) and also reactions such as swelling, pain and redness are described as side effects of vaccination. Severe side effects after pneumococococcal vaccination are very rare (in one of 100,000 children).